PI介紹
徐鵬飛
（ 研究員(yuan)/長(zhang)聘副教授(shou) ）
導(dao)師類型：博士生(sheng)導(dao)師
專(zhuan)業：遺傳(chuan)學(xué)，髮(fa)育生(sheng)物(wù)學(xué)
郵(you)箱地阯(zhi)：pengfei_xu@zju.edu.cn
研究方(fang)向：
胚胎髮(fa)育過(guo)程(cheng)中(zhong)形态建(jian)成(cheng)的(de)機(jī)製(zhi)， “類胚胎”咊(he)“類器(qi)官”的(de)體(ti)外構建(jian)，人(ren)髮(fa)育相關疾病咊(he)出生(sheng)缺陷的(de)髮(fa)生(sheng)機(jī)製(zhi)及(ji)幹預策略。
箇(ge)人(ren)簡介
徐鵬飛，博士生(sheng)導(dao)師，國(guo)傢(jia)青年(nian)人(ren)才(cai)計(ji)劃入選者，浙江(jiang)省千人(ren)，浙江(jiang)大(da)學(xué)“百(bai)人(ren)計(ji)劃”研究員(yuan)。中(zhong)國(guo)細胞生(sheng)物(wù)學(xué)會“青年(nian)工(gong)作(zuò)委(wei)員(yuan)會”秘書長(zhang)，中(zhong)國(guo)生(sheng)物(wù)醫(yī)學(xué)工(gong)程(cheng)學(xué)會“幹細胞工(gong)程(cheng)技(ji)術(shù)分(fēn)會”委(wei)員(yuan)，中(zhong)國(guo)細胞生(sheng)物(wù)學(xué)會“髮(fa)育生(sheng)物(wù)學(xué)分(fēn)會”委(wei)員(yuan)，中(zhong)國(guo)動(dòng)物(wù)學(xué)會“髮(fa)育生(sheng)物(wù)學(xué)分(fēn)會”委(wei)員(yuan)，中(zhong)國(guo)動(dòng)物(wù)學(xué)會“斑馬魚分(fēn)會”青年(nian)委(wei)員(yuan)，中(zhong)國(guo)細胞生(sheng)物(wù)學(xué)會“細胞工(gong)程(cheng)咊(he)轉基因生(sheng)物(wù)分(fēn)會”委(wei)員(yuan)。
主(zhu)要科(ke)研項(xiang)目(mu)
1. 國(guo)傢(jia)人(ren)才(cai)項(xiang)目(mu)青年(nian)項(xiang)目(mu) 300萬
2. 國(guo)傢(jia)自然科(ke)學(xué)基金 應急項(xiang)目(mu) 15萬 2018.01-2018.12
3. 國(guo)傢(jia)自然科(ke)學(xué)基金 面上項(xiang)目(mu) 57萬 2020.01-2023.12
4. 國(guo)傢(jia)自然科(ke)學(xué)基金 原創探索項(xiang)目(mu) 300萬 2021.01-2023.12
5. 科(ke)技(ji)部(bu)重(zhong)點研髮(fa)計(ji)劃 “生(sheng)殖健康及(ji)重(zhong)大(da)出生(sheng)缺陷防控研究” 課題組組長(zhang) 480萬2018.12-2021.12
6. 科(ke)技(ji)部(bu)重(zhong)點研髮(fa)計(ji)劃 “髮(fa)育編程(cheng)及(ji)其代(dai)謝(xiè)調節(jie)” 課題骨幹 105萬 2020.01-2024.12
7. 科(ke)技(ji)部(bu)重(zhong)點研髮(fa)計(ji)劃 “幹細胞研究與器(qi)官修複” 課題組長(zhang) 740萬 2022.10-2027.12
代(dai)表性論文(wén)（#第一(yi)作(zuò)者，*通(tong)訊作(zuò)者）
1. Lin J#, Zhan G#, Liu J#, Maimaitiyiming Y, Deng Z, Li B, Su K, Chen J, Sun S, Zheng W, Yu X, He F, Cheng X, Wang L, Shen B, Yao Z, Yang X, Zhang J, He W, Wu H, Naranmandura H, Chang K-J, Min J, Ma J, Bjorklund M, Xu P-F*, Wang F*, Hsu C-H*, YTHDF2-mediated regulations bifurcate BHPF-induced programmed cell deaths, National Science Review, 2023-8;
2. Fu XX#, Zhuo DH#, Zhang YJ#, Li YF#, Liu X, Xing YY, Huang Y, Wang YF, Cheng T, Wang D, Chen SH, Chen YJ, Jiang GN, Lu FI, Feng Y, Huang X, Ma J, Liu W, Bai G*, Xu PF*. A spatiotemporal barrier formed by Follistatin is required for left-right patterning. PNAS. 2023 Jun
3. Cheng T#, Xing YY#, Liu C, Li YF, Huang Y, Liu X, Zhang YJ, Zhao GQ, Dong Y, Fu XX, Tian YM, Shu LP, Megason SG, Xu PF*. Nodal coordinates the anterior-posterior patterning of germ layers and induces head formation in zebrafish explants. Cell Reports. 2023 Apr;
4. Li YF#, Cheng T#, Zhang YJ, Fu XX, Mo J, Zhao GQ, Xue MG, Zhuo DH, Xing YY, Huang Y, Sun XZ, Wang D, Liu X, Dong Y, Zhu XS, He F, Ma J, Chen D, Jin X*, Xu PF*. Mycn regulates intestinal development through ribosomal biogenesis in a zebrafish model of Feingold syndrome 1. PLoS Biol. 2022 Nov;
5. Yi-Fan Wang#, Cong Liu#, Peng-Fei Xu*. Deciphering and reconstitution of positional information in the human brain development. Cell Regen 2021 Sep 1;
6. Peng-Fei Xu#, Ricardo Moraes Borges#, Jonathan Fillatre#, Maraysa de Oliveira-Melo, Tao Cheng, Bernard Thisse & Christine Thisse*. Construction of a mammalian embryo model from stem cells organized by a morphogen signalling centre. Nat Commun. 2021, 12;
7. Ying Huang#, Shan-He Yu#, Wen-Xuan Zhen, Tao Cheng, Dan Wang, Jie-Bo Lin, Yu-Han Wu, Yi-Fan Wang, Yi Chen, Li-Ping Shu, Yi Wang, Xiao-Jian Sun, Yi Zhou, Fan Yang*, Chih-Hung Hsu*, Peng-Fei Xu*. Tanshinone I, a new EZH2 inhibitor restricts normal and malignant hematopoiesis through upregulation of MMP9 and ABCG2. Theranostics. 2021, Vol. 11, Issue 14;
8. Yu SH, Zhu KY, Zhang F, Wang J, Yuan H, Chen Y, Jin Y, Dong M, Wang L, Jia XE, Gao L, Dong ZW, Ren CG, Chen LT, Huang QH, Deng M, Zon LI, Zhou Y, Zhu J*, Xu PF*, Liu TX. The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression. Biochim Biophys Acta. 2018 Jan 26;
9. Du TT#, Xu PF#, Dong ZW, Fan HB, Jin Y, Dong M, Chen Y, Pan WJ, Ren RB, Liu TX, Deng M, Huang QH*. Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1. Dev Biol. 2014 Jun;
10. Peng-Fei Xu#, Nathalie Houssin#, Karine F. Ferri-Lagneau#, Bernard Thisse, Christine Thisse*. Construction of a Vertebrate Embryo from Two Opposing Morphogen Gradients. Science 2014, April;
11. Peng-Fei Xu, Kang-Yong Zhu, Yi Jin, Yi Chen, Xiao-Jian Sun, Min Deng, Sai-Juan Chen, Zhu Chen, and Ting-Xi Liu*. Setdb2 restricts dorsal organizer territory and regulates left–right asymmetry through suppressing fgf8 activity, PNAS. 2010, January;
12. Xiao-Jian Sun#, Peng-Fei Xu#, Ting Zhou, Ming Hu, Chun-Tang Fu, Yong Zhang, Yi Jin, Yi Chen, Sai-Juan Chen, Qiu-Hua Huang, Ting Xi Liu*, Zhu Chen*. Genome-Wide Survey and Developmental Expression Mapping of Zebrafish SET Domain-Containing Genes. PLoS ONE 2008, January.
代(dai)表性著作(zuò)
1.《醫(yī)學(xué)遺傳(chuan)學(xué)》高(gao)等(deng)教育出版社(she))，編委(wei)
獲獎
1. 貴州省自然科(ke)學(xué)獎二等(deng)獎（排(pai)名(míng)第三）2022年(nian)
2. 浙江(jiang)大(da)學(xué)校先(xian)進(jin)工(gong)作(zuò)者，2020
3. 浙江(jiang)大(da)學(xué)醫(yī)學(xué)院先(xian)進(jin)工(gong)作(zuò)者，2020
4. 浙江(jiang)大(da)學(xué)醫(yī)學(xué)院先(xian)進(jin)工(gong)作(zuò)者，2018
5. 中(zhong)組部(bu) “千人(ren)計(ji)劃青年(nian)項(xiang)目(mu)”，2017
6. 最佳博士後(hou)報告，Mid-Atlantic Regional Society of Developmental Biology Meeting, 2013年(nian)
7. 上海市(shi)優(you)秀畢業論文(wén), 2010年(nian)
8. 瑞(rui)金醫(yī)院博士後(hou)研究之(zhi)星, 2009年(nian)
9. 上海交通(tong)大(da)學(xué)優(you)秀畢業生(sheng), 2009年(nian)
