楊小(xiǎo)杭(hang)，浙江(jiang)大(da)學(xué)教授(shou)，博士生(sheng)導(dao)師。1982年(nian)杭(hang)州大(da)學(xué)生(sheng)物(wù)係(xi)本(ben)科(ke)畢業後(hou)，進(jin)入中(zhong)科(ke)院上海植物(wù)生(sheng)理(li)所。稍後(hou)考入CUSBEA項(xiang)目(mu)，1983年(nian)就讀于(yu)美國(guo)Dartmouth大(da)學(xué)醫(yī)學(xué)院生(sheng)化係(xi)，于(yu)1988年(nian)獲得生(sheng)物(wù)化學(xué)博士，同年(nian)到(dao)麻省理(li)工(gong)學(xué)院生(sheng)物(wù)係(xi)做博士後(hou)。1989年(nian)底去新(xin)加(jia)坡分(fēn)子(zi)細胞研究所工(gong)作(zuò)，歷(li)任博士後(hou)（William Chia’s Lab），研究員(yuan)（Principal Investigator） 咊(he)高(gao)級研究員(yuan)（Senior Principal Investigator）。1991-1993年(nian)，在(zai)新(xin)加(jia)坡榮獲李光耀博士後(hou)獎（Lee Kuan Yew Postdoctoral Fellowship）；2001年(nian)，獲得新(xin)加(jia)坡國(guo)傢(jia)科(ke)學(xué)獎 （備(bei)注：該獎項(xiang)昰(shi)新(xin)加(jia)坡科(ke)研最高(gao)榮譽獎，與William Chia共享）。2010年(nian)9月，全職回浙江(jiang)大(da)學(xué)工(gong)作(zuò)。

楊小(xiǎo)杭(hang)博士多(duo)年(nian)從(cong)事幹細胞不對稱分(fēn)裂及(ji)果蠅神經(jing)髮(fa)育生(sheng)物(wù)學(xué)研究，早期專(zhuan)注于(yu)神經(jing)細胞命運決定的(de)調控機(jī)製(zhi)研究，率先(xian)報道果蠅胚胎中(zhong)樞神經(jing)係(xi)統內(nei)特異表達的(de)兩箇(ge)色胺酸去磷酸化酶；POU蛋白咊(he)Klumpfus蛋白對調控神經(jing)母細胞（Ganglion Mother Cell）特異性命運的(de)作(zuò)用(yong)；Staufen蛋白在(zai)神經(jing)幹細胞不對稱分(fēn)裂中(zhong)的(de)功能(néng)；首次報道如Snail傢(jia)族轉錄因子(zi)以(yi)及(ji)Pins咊(he)Gai在(zai)幹細胞不對稱分(fēn)裂中(zhong)的(de)作(zuò)用(yong)機(jī)理(li)，神經(jing)幹細胞分(fēn)裂過(guo)程(cheng)中(zhong)紡錘體(ti)不對稱性的(de)調控，以(yi)及(ji)神經(jing)幹細胞分(fēn)裂末期矯正現(xian)象的(de)分(fēn)子(zi)機(jī)理(li)等(deng)。回浙大(da)後(hou)，研究工(gong)作(zuò)聚(ju)焦在(zai)基因變異導(dao)緻的(de)遺傳(chuan)疾病，利用(yong)模式(shi)動(dòng)物(wù)果蠅解析相關疾病的(de)緻病原理(li)咊(he)機(jī)製(zhi)。這些工(gong)作(zuò)髮(fa)表在(zai)Cell、Genes & Dev、EMBO J、Development等(deng)雜志(zhì)上。

• 1、 國(guo)傢(jia)自然科(ke)學(xué)基金，31371381，“線(xiàn)粒體(ti)內(nei)膜基因chch1 與Hippo 信(xin)号通(tong)路控製(zhi)果蠅器(qi)官大(da)小(xiǎo)的(de)分(fēn)子(zi)機(jī)理(li)研究”，2014/01-2017/12, 已結題，主(zhu)持。

• 2、 國(guo)傢(jia)重(zhong)大(da)科(ke)學(xué)研究計(ji)劃，2013CB945600，“神經(jing)前(qian)體(ti)細胞命運決定、分(fēn)化及(ji)環路形成(cheng)的(de)調控機(jī)製(zhi)”課題一(yi)，2013/01-2017/12，已結題，首席科(ke)學(xué)傢(jia)。

• 3、 國(guo)傢(jia)重(zhong)大(da)科(ke)學(xué)研究計(ji)劃，2012CB966800，“幹細胞分(fēn)裂模式(shi)咊(he)幹性維(wei)持機(jī)製(zhi)研究”課題四，2012/01-2016/12，已結題，科(ke)研骨幹。

• 1) The FAcilitates Chromatin Transcription complex regulates the ratio of glycolysis to oxidative phosphorylation in neural stem cells. Lou Y, Wu L, Cai W, Deng H, Sang R, Xie S, Xu X, Yuan X, Wu C, Xu M, Ge W, Xi Y, Yang X.J Mol Cell Biol. 2024 May 8:mjae017. doi: 10.1093/jmcb/mjae017.

• 2) Xie S, Xu C, Wu C, Lou Y, Duan J, Sang R, Lou Z, Hou J, Ge W, Xi Y, Yang X. Co-dependent regulation of p-BRAF and potassium channel KCNMA1 levels drives glioma progression. Cell Mol Life Sci.10; 80 （2023）doi: 10.1007/s00018-023-04708-9. PMID: 36763212;

• 3) Rong Sang, Cheng Wu, Shanshan Xie, Xiao Xu, Yuhan Lou, Wanzhong Ge, Yongmei Xi & Xiaohang Yang. Mxc, a Drosophila homolog of mental retardation-associated gene NPAT, maintains neural stem cell fate. Cell Biosci 12, 78 (2022). https://doi.org/10.1186/s13578-022-00820-8. 

• 4) Huimei Zheng, Ziwei Lou, Xin Yuan, Haoyue Wu, Xiaohang Yang, Yongmei Xi. Phosphatase of Regenerating Liver-1 Regulates Wing Vein Formation through TGF-β Pathway in Drosophila melanogaster. Front Biosci (Landmark Ed). 2022 Jun 1;27(6):176. doi: 10.31083/j.fbl2706176. PMID: 35748252.

• 5) Wu, D，Wu, L, An, H, Bao, H, Guo, P, Zhang, B, Zheng, H, Zhang, F, Ge, W, Cai, Y, Xi, Y. and Yang, X. (2019) RanGAP-mediated nucleocytoplasmic transport of Prospero regulates neural stem cell lifespan in Drosophila larval central brain. Aging Cell，Feb;18(1):e12854

• 6) An, H., Ge,W., Xi, Y. and Yang, X.（2017）Inscuteable Maintains Type I Neuroblast Lineage Identity via Numb/Notch Signaling in the Drosophila Larval Brain JGG, 44, 151-162 

• 7) Zhang, F., Huang, Z.X., Bao, H.C., Cong, F., Wang, H.S., Chai, P.C., Xi, Y., Ge, W., Somers W.G., Cai, Y. and Yang, X. (2016) Phosphotyrosyl phosphatase activator facilitates localization of Miranda through dephosphorylation in dividing neuroblasts. Development, 143(1) 35-44

• 8) Wang H, Cai Y, Chia W and Yang X. Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts. EMBO J 2006，25：5783–5793. 

• 9) Yu F, Wang H, Qian H, Kaushik R, Bownes M, Yang X and Chia W. Locomotion defects, together with Pins, regulates heterotrimeric G-protein signaling during Drosophila neuroblast asymmetric divisions. Gen & Dev. 2005, 19: 1341-1353.

• 10) Cai Y, Yu F, Lin S, Chia W. and Yang X. Apical Complex Genes Control Mitotic Spindle Geometry and Relative Size of Daughter Cells in Drosophila Neuroblast and pI Asymmetric Divisions. Cell 2003, 112: 51-62.

• 11) Yu F, Cai Y, Kaushik R, Yang X and Chia W. Distinct roles of Gai and Ga13F subunits of the heterotrimeric G protein complex in the mediation of Drosophila neuroblast asymmetric divisions. J Cell Biol 2003, 162: 623-633

• 12) Yu F, Morin X, Kaushik R, Bahri S, Yang X and Chia W. A mouse homologue of Drosophila pins can asymmetrically localize and substitute for pins function in Drosophila neuroblasts. J Cell Sci 2003, 116: 887-896.

• 13) Yu F, Ong CT, Chia W and Yang X. Membrane targeting and asymmetric localisation of Drosophila Partner of Inscuteable are discrete steps controlled by distinct regions of the protein. MCB 2002, 22: 4230-4240.

• 14) Cai Y, Chia W and Yang X. A family of Snail related zinc-finger proteins regulates two distinct and parallel mechanisms which mediate Drosophila neuroblast asymmetric divisions   EMBO J 2001, 20: 1704-1714.

• 15) Bahri SM, Chia W and Yang X. Characterization and mutant analysis of the Drosophila Sema 5C gene. Dev Dyn 2001, 221: 322-330.

• 16) Cheah PY, Chia W and Yang X. Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates. Development 2000, 127: 3325-3335. 

• 17) Yu F, Morin X, Cai Y, Yang X and Chia W. Analysis of partner of inscuteable, a Novel Player of Drosophila Asymmetric Divisions, Reveals Two Distinct Steps in Inscuteable Apical Localization. Cell 2000, 100: 399-409.

• 18) Li P, Yang X, Wasser M, Cai Y. & Chia W. Inscuteable and Staufen are required for the asymmetric localisation and segregation of Prospero RNA during Drosophila  neuroblast cell divisions. Cell 1997, 90: 437-447.

• 19) Yang X, Bahri S, Klein T. & Chia W. Klumpfus, a putative Drosophila Zn-finger transcription factor, acts to differentiate between the identities of two secondary progenitor cells from one neuroblast lineage. Gen & Dev 1997, 11: 1396-1408.

• 20) Yang X, Yeo S, Dick T and Chia W. The Role of a Drosophila POU Homeo Domain gene in the Specification of Neural Precursor Cell Indetity in the Developing Embryonic Central Nervous System. Gen & Dev 1993, 7: 504-516.

• 21) Yang X, Seow KT, Bahri SM, Oon SH and Chia W. Two Drosophila Receptor-like Tyrosine Phosphotase Genes Are Expressed in a Subset of Developing Axons and Pioneer Neurons in the Embryonic CNS. Cell 1991, 67: 661-673.