2005年(nian)畢業于(yu)浙江(jiang)大(da)學(xué)醫(yī)學(xué)院婦科(ke)腫瘤專(zhuan)業，獲博士學(xué)位。近年(nian)來一(yi)直從(cong)事婦科(ke)腫瘤的(de)分(fēn)子(zi)生(sheng)物(wù)學(xué)髮(fa)病機(jī)製(zhi)的(de)研究，在(zai)國(guo)內(nei)外核心學(xué)術(shù)期刊上髮(fa)表論文(wén)三十餘篇。參與婦女生(sheng)殖與健康重(zhong)點實驗(yàn)室的(de)建(jian)設(shè)，指導(dao)研究生(sheng)從(cong)事婦科(ke)惡性腫瘤的(de)分(fēn)子(zi)生(sheng)物(wù)學(xué)基礎研究。

研究方(fang)向：
1、婦科(ke)腫瘤
2、分(fēn)子(zi)腫瘤學(xué)

承(cheng)擔科(ke)研項(xiang)目(mu)：
1.siRNA表觀遺傳(chuan)學(xué)上調控宮頸癌HPV16癌基因表達分(fēn)子(zi)靶點。高(gao)等(deng)學(xué)校博士學(xué)科(ke)點專(zhuan)項(xiang)科(ke)研基金，2008.1-2010.12，排(pai)名(míng)1/9
2.染色體(ti)11q22－q25區(qu)候選抑癌基因高(gao)甲基化咊(he)宮頸癌的(de)髮(fa)生(sheng)機(jī)製(zhi)，浙江(jiang)省自然基金（Y205190），2006.1-2008.12，排(pai)名(míng)：1/7
3.喜樹堿對耐紫杉醇卵巢癌細胞的(de)作(zuò)用(yong)機(jī)製(zhi)研究，浙江(jiang)省中(zhong)醫(yī)藥跼(ju)（2006C089），2006.1－2007.12，排(pai)名(míng)：1/7
4.Notch蛋白及(ji)其靶基因Hes1、Hes5在(zai)宮頸癌細胞分(fēn)化中(zhong)作(zuò)用(yong)的(de)研究，浙江(jiang)省衛生(sheng)廳青年(nian)項(xiang)目(mu)（2006QN018），2006.7-2008.12，排(pai)名(míng)：1/4
5.抑癌基因啓動(dòng)子(zi)CpG島高(gao)甲基化與宮頸癌髮(fa)生(sheng), 浙江(jiang)省教育廳（ 20050971）, 2005.7- 2006.12，排(pai)名(míng)1/6
6.卵巢癌腫瘤幹細胞的(de)分(fēn)離、鑒定及(ji)其在(zai)化療耐藥中(zhong)的(de)分(fēn)子(zi)機(jī)製(zhi)。浙江(jiang)省衛生(sheng)廳面上項(xiang)目(mu)（2007A129），2007.7- 2009.12，排(pai)名(míng)1/8

代(dai)表性論著：
(1)Ye F, Chen HZ, Xie X, Ye DF, Lu WG, Ding ZM. Vascular endothelial growth factor (VEGF) and ovarian carcinoma cell supernatant activate signal transducers and activators of transcription (STATs) via VEGF receptor-2 (KDR) in human hemopoietic progenitor cells. Gynecol Oncol. 2004 Jul;94(1):125-33.
(2)Ye F, Chen HZ, Xie X, Ye DF, Lu WG. Ovarian carcinoma cells effectively inhibit differentiation and maturation of dendritic cells derived from hematopoietic progenitor cells in vitro. Cancer Invest. 2005;23(5):379-85.
(3)Ye F, Chen HZ, Liang ZX, Lu WG, Cheng Q, Xie X. Establishment of Cervical Cancer Model via Inoculating SiHa Cells into Humanized Severe Combined Immunodeficient Mice. Eur J Gynaecol Oncol. 2006;27(6):566-72.
(4)Ye F, Zhang SF, Xie X, Lu WG. OPCML Gene Promoter Methylation and Gene Expression in Tumor and Stroma Cells of Invasive Cervical Carcinoma. Cancer Invest. 2008, accepted.
(5)Huang J, Ye F, Chen H, Lu W, Xie X. Amino acid substitution polymorphisms of the DNA repair gene MGMT and the susceptibility to cervical carcinoma. Carcinogenesis. 2007 Jun;28(6):1314-22. Epub 2007 Jan 18.
(6)Huang J, Ye F, Chen H, Lu W, Xie X. The nonsynonymous single nucleotide polymorphisms of DNA repair gene XRCC1 and susceptibility to the development of cervical carcinoma and high-risk human papillomavirus infection. Int J Gynecol Cancer. 2007 May-Jun;17(3):668-75.
(7)Li X, Ye F, Chen H, Lu W, Wan X, Xie X. Human ovarian carcinoma cells generate CD4(+)CD25(+) regulatory T cells from peripheral CD4(+)CD25(-) T cells through secreting TGF-beta. Cancer Lett. 2007 Aug 8;253(1):144-53.
(8)Zhou JH, Ye F, Chen HZ, Zhou CY, Lu WG, Xie X. Altered expression of cellular membrane molecules of HLA-DR, HLA-G and CD99 in cervical intraepithelial neoplasias and invasive squamous cell carcinoma. Life Sci. 2006 Apr 25;78(22):2643-9. Epub 2006 Jan 24.
(9)Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X. Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors. Int J Gynecol Cancer. 2007 Nov-Dec;17(6):1293-9.
(10)Hong D, Ye F, Chen H, Lü W, Cheng Q, Hu Y, Xie X. Distribution of human papillomavirus genotypes in the patients with cervical carcinoma and its precursors in Zhejiang Province, China. Int J Gynecol Cancer. 2007 Apr 26;
(11)Chen H, Ye F, Zhang J, Lu W, Cheng Q, Xie X. Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinoma. Eur J Gynaecol Oncol. 2007;28(6):464-7.
(12)Ma Y, Ye F, Lv W, Cheng Q, Chen H, Xie X. Correlation between soluble Fas level and apoptosis of T cells in ovarian carcinoma. Eur J Obstet Gynecol Reprod Biol. 2007 Sep 7; [Epub ahead of print]
(13)Lu WG, Ye F, Shen YM, Fu YF, Chen HZ, Wan XY, Xie X. EMA-CO chemotherapy for high-risk gestational trophoblastic neoplasia: a clinical analysis of 54 patients. Int J Gynecol Cancer. 2007 Aug 17; [Epub ahead of print]
(14)Chen, H; Ye, F; Zhang, J; Lu, W; Cheng, Q; Xie, X. Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinoma. Eur J Gynaecol Oncol. 2008; [Epub ahead of print]